n Chatwins has invested £40,000 in setting up a new venture called Chatwins Direct. The bakery will deliver lunch to workers in the Crewe and Nantwich area, including sandwiches, drinks, homemade soups, pies and pasties. Chatwins aims to create a fleet of eight vehicles over the next year.n Krispy Kreme has introduced a new whole wheat glazed doughnut to its menu in America. The new product, made from 100% caramel-flavoured whole wheat, has 180 calories. The company, which has 395 stores worldwide, is trying to attract health-conscious consumers.n Artist Christina Mingard will work in the gallery above The Village Bakery in Melmerby, Cumbria. She will be joined by a number of artists to paint the scenes from the gallery windows throughout the year. At the beginning of March, Ken Spencer from Northumberland will join her for two months.n The California Raisins Administrative Committee has announced its fourth annual Innovation Award with a trip to California up for grabs. It is looking for innovative uses of raisins. The closing date for the competition is 31 May.n SHM Smith Hodgkinson, an auctioneer, has been appointed on behalf of KPMG to sell off food manufacturing equipment for Bonne Bouche Frozen (UK). The frozen cake and dessert manufacturer, based in Hartlepool, went into liquidation in February. The sale is set to take place from 16 to 19 April.
QPR are among several clubs interested in Southampton’s former Chelsea midfielder Jack Cork, the Mail say.Crystal Palace, Swansea and West Brom are also said to be keen on the 25-year-old, who has a year left on his Saints contract.There continues to be speculation over the future of Loic Remy, with Arsenal reported to have pulled out of the supposed race to sign him from QPR.The Express suggest this will pave the way for a possible move to Tottenham or Liverpool for the France striker.Related West London Sport story: QPR chairman wants Remy’s future resolvedReports in Italy suggest Juventus are interested in signing Adel Taarabt from QPR following his recent loan spell at AC Milan.Taarabt’s future is uncertain following his return to Rangers.Meanwhile, the Express claim Chelsea are battling with Atletico Madrid for the signing of Napoli’s Jose Callejon.The Express also say defender Raphael Varane, who is apparently a Chelsea target, is unhappy with his Real Madrid contract.For more transfer speculation, including QPR being linked with Watford striker Troy Deeney, see this morning’s Paper Talk.See also:Rangers interested in forwards Deeney and Barrow, reports claimFollow West London Sport on TwitterFind us on Facebook
It’s a good time to be a Neanderthal. You’ll get more respect than ever before from paleoanthropologists. The latest example, published in PhysOrg, is headlined, “Neanderthals more advanced than previously thought.” Julien Riel-Salvatore [U of Colorado at Denver] says he is “rehabilitating Neanderthals” by challenging a half-century of “conventional wisdom” that portrayed them as numbskulls. His studies in Italy show Neanderthals to be creative, adaptable and successful, coming up with tools, art and hunting implements on their own without “modern human” help. “We are more brothers than distant cousins,” he thinks. See also the 05/08/2010 entry.Update: National Geographic just published a strange new idea: that volcanoes killed off the Neanderthals. Ker Than explained that major volcanic eruptions near the Caucasus Mountains so damaged their habitat they were unable to bounce back. This flies in the face of a long-standing theory that modern humans proved too brainy for them and pushed them off the world stage. And didn’t Neanderthals cover a wide area from northern Europe to the Middle East? Other anthropologists were quoted with objections to the new idea.It’s going to take a long time to undo the Neanderthal myth because of the Law of Inertia for Falsified Theories (01/15/2010).(Visited 10 times, 1 visits today)FacebookTwitterPinterestSave分享0
(Visited 21 times, 1 visits today)FacebookTwitterPinterestSave分享0 The more we learn about a vital molecular machine in the nucleus, the spliceosome, the more complex and important it seems.The spliceosome is a large “slicer and dicer” that takes DNA transcripts (messenger RNA) and prepares them for export out of the nucleus, where they will be translated into proteins. Science Daily described what molecular biologists have learned about this amazing multi-function machine:The process of splicing is carried out by a highly complex molecular machine termed the spliceosome. Human spliceosomes are built up from protein and RNA molecules. They contain some 170 different proteins and five RNA molecules termed “small nuclear RNAs” (snRNAs). It is currently believed that certain snRNAs represent the tools with which the spliceosome carries out the cutting and joining of RNA sections, turning the messenger RNA’s precursor (“pre‑mRNA”) into mature messenger RNA. The proteins of the spliceosome are needed to bring these tools to the right place at the right time, and to set them into operation. Splicing processes in higher organisms are very highly regulated. In fact, differing patterns of excision and joining of a given pre‑mRNA molecule can lead to any one of a selection of different mature mRNA molecules — all from the same gene. This ability to select the mRNA product according to need is termed “alternative splicing,” and it is thought to be the most important means by which human cells manage to produce a vast spectrum of different proteins from a relatively restricted number of protein-encoding genes.So far, we’ve seen precision tools that arrive at precision times to do precision jobs. We’ve seen that this multi-part, complex machine, aided by multiple other proteins and small RNA molecules, is capable of turning a transcribed gene into a vast array of protein templates by means of alternative splicing. Years ago, it seemed a mystery why genes contained many apparently useless regions of code, dubbed introns, that had to be cut out of the messenger RNA (see 9/03/2003). The spliceosome’s magic of alternative splicing is providing clues.The article, based on a press release from the Free University of Berlin, used some pithy analogies to help readers understand the process. One of the tools was likened to a knife in a sheath, that safely moves to the cutting site, waits for a “start signal,” then unsheathes itself and goes to work. The start signal is given by another machine with a “remarkable molecular architecture” that enables the knife. But that start-signal machine is held on a short leash by another machine, preventing it from giving the start signal. That machine acts like a “plug in a stopper,” the researchers said, making sure the start signal is only given at the right time.But then, the researchers found another machine that works in tandem with the “plug,” regulating the “start signal” independently. “The existence of two or more different mechanisms to regulate the same cellular process underlines the importance of the exact timing of this process for the overall process of RNA splicing,” one of the researchers said.This information is not just academic. “In humans, errors in this control mechanism can lead to blindness.” Could this machine have evolved by chance? The article does not mention evolution. It did say, though, that the spliceosome has some 170 different proteins. Could chance build just one protein? (See our online book for the unforgettable answer.)We in this century are so privileged to get glimpses into the inner workings of life at its most basic level. What would Aristotle or Galen, Leeuwenhoek or Darwin, thought if they knew that machinery—cutting tools, stoppers, regulators and other moving parts—so tiny as to be invisible without highly sophisticated human machinery—were keeping us alive? Every second, every minute we are being upheld by trillions of machines like this that nobody even suspected were possible till the age of molecular biology.Had Darwin known this, he might never have dared to write a story that blind, unguided processes could explain life. There’s an interesting novella on that theme that was recently presented on ID the Future in audio format, 5 episodes. “I, Charles Darwin” transports the bearded buddha into the 21st century, where he learns about these wonders and responds to them. To encourage you to listen, we won’t spoil the end of the story.
Shado Twala and Randall Abrahams, judges on South Africa’s hit reality TV show SA’s Got Talent add their voices to the national outpouring of support for the country’s Class of 2010, who began sitting their Grade 12 exams this week.Click arrow to play video.Published on SouthAfrica.info on 28 October 2010.Source: Fly the Flag Fridays
It’s free … so sign up already!The 2009 energy codes are out, and soon they will be adopted in your state or municipality. To get a quick handle on the changes, the Department of Energy (DOE) is providing a free webcast on Tuesday, June 16, on the residential aspects (requirements) of the 2009 International Energy Conservation Code (IECC).Follow this link to the free sign-up: http://www.energycodes.gov/training/onlinetraining/residential2009IECC.stmTodd Taylor of the Pacific Northwest Laboratory will host the one-hour presentation. Afterward, there will be a 30-minute question-and-answer session.The IECC is one of two options available to homebuilders for demonstrating energy code compliance. While the International Residential Code (IRC) is the primary energy code for one and two family dwellings, Section N1101.2 offers the IECC as an equivalent alternative. The IECC is more performance driven and allows component trade-offs through a simulated performance alternative provision (Section 405).This performance-based approach has always been considered more flexible than the prescriptive aspects of Chapter 11 of the IRC. While still flexible, the IECC has tightened it up somewhat with the introduction of some mandatory components–items that formerly were considered suitable alternative materials or techniques. This change in their status essentially disallows their use as trade-offs. Certain mechanical equipment is among these mandatory components, and others will likely be discussed in the webcast.The DOE has always been a key player in the development of the Model Energy Codes. Its role in the development of the 2009 edition is no exception; many of the significant changes in the 2009 codes were introduced by the agency, and significant testimony was offered by its representatives in both model codes in the 2009 editions. This testimony heavily influenced the changes that will be discussed.
If I drop my iPhone 5 on the sidewalk, how easily will it be to repair the screen? What if my Kindle Fire’s battery stops holding a charge? When we’re shopping for new tablets and smartphones, we seldom take these kinds of things into consideration. Most of us just presume nothing bad will happen. And if it does, well, we’ll deal with it when it happens. As far as the manufacturers are concerned, they’re usually more interested in getting customers to stand in line for the new gadget in another year or two, so making it easy to fix today’s devices is hardly a priority. If you look at the user manual of an iPad, Kindle Fire or Nexus 7, you won’t see instructions on replacing the battery – or opening the device for any purpose. iPhones are held together using proprietary pentalobe screws specifically designed to keep you out of your device’s innards. Whether we like it or not, we’re living in the Age of Unrepairable Machines. As our devices get more portable and sleek, our ability to tweak and repair the hardware diminishes. (The ability to work with the software, of course, is a separate question.)Some argue that this is okay. Most of us wouldn’t want to fix our refrigerators or our watches if they break, so why bother with tablets and smartphones? Computers Used To Be Hobbyist FavoritesThe thing is, historically, computers have been easily modified by their owners. In fact, that ability to fix, upgrade and otherwise tinker with computers was a big part of the genre’s early appeal. So while you can’t crack open an iPad to add more memory like you can with your laptop, there are still plenty of consumers who would prefer the do-it-yourself route to replacing busted screens and dead batteries. But how realistic is that in 2013? Just how fixable is that tablet you’re thinking of buying?Thankfully you don’t have to wait until the screen shatters to find out. The folks over at iFixIt have been tearing down the hottest new gadgets as they’re released and posting detailed, step-by-step reports on the guts of each one. We put together this handy chart of how iFixIt ranks popular smartphones and tablets: john paul titlow 7 Types of Video that will Make a Massive Impac… How to Write a Welcome Email to New Employees? Why You Love Online Quizzes Note: If you’re the DIY Mr(s).-Fix-It type, we definitely recommend reading through your gadget’s teardown report with care before breaking out the 54-bit driver set. And keep in mind that none of these manufacturers intend for you to open their devices, so do so at your own risk. Photo courtesy of iFixIt. Growing Phone Scams: 5 Tips To Avoid Related Posts Tags:#Gadgets#iPad#iPad mini#iPhone 5#Kindle Fire#Surface Pro
4. Neumann FilmsPerfect for CinematographersThe Neumann Films YouTube channel gets instant credibility with their fantastic cinematic image quality. Their videos tell you exactly how they get their incredibly cinematic shots and effects. Specifically, Neumann Films takes a focus on color grading and frame rates. If you’re serious about quality than Neumann Films is a great resource. Not all of their videos are free — but if you don’t mind spending a few dollars, the paid content is definitely worth it.Notable Episode: Sony FS700 – Epic Slow Mo 9. PremiumBeat (Shameless Plug)Perfect for Well-Rounded FilmmakersIf you’re reading this, then you’re probably already familiar with the incredibly extensive blog here at PremiumBeat. Besides having one of the largest filmmaking blogs in the world, PremiumBeat also has an extensive YouTube channel that covers various topics, from After Effects to Cinematography.Notable Episode: Cinematography Tutorial: Dramatic Camera Slider MovesWhat about you? What are your favorite websites to learn about filmmaking? Share in the comments below. 3. Dave DugdalePerfect for Gear LoversDave Dugdale’s YouTube channel is unique because he takes the stance of a curious filmmaker that is learning at the same time he is teaching you. Through his humble attitude towards equipment, he shares his experience with cameras, equipment, and software. Most of Dave’s videos focus around highly specific comparisons and tests, which makes his channel fantastic for gear lovers. Notable Episode: Black Magic Pocket Camera Review Compared To DSLR and Red Epic 7. Philip BloomPerfect for Travel FilmmakersPhilip Bloom is probably the biggest indie-filmmaking celebrity in the world and for a good reason. With killer reviews, cinematic quality videos, and a sense of style that would fit the cover of GQ magazine, Philip Bloom brings us helpful tutorials and he has the skills to back it up. In addition to his YouTube channel, his site is also a great place to find helpful articles and resources. Philip cruises the world looking for awesome things to video, review, and test, which makes his channel a great source of inspiration as well.Notable Episode: Now I See (A7S Test) 2. Filmmaker IQPerfect for Filmmaking NerdsFilmmaker IQ is a YouTube channel (and site) dedicated to helping filmmakers learn the craft of filmmaking on a fundamental level. Unlike other filmmaking channels, Filmmaker IQ puts film techniques in the context of film history as a whole. You won’t just learn how to record sound, you’ll learn the fundamentals of how sound waves work and how they hit a microphone. If you’re looking for an extremely well-rounded filmmaking education, Filmmaker IQ is for you.Notable Episode: The History of Frame Rate for Film 8. Every Frame a PaintingPerfect for DirectorsFilmmaking is an art form, but you didn’t need me to tell you that. While it may seem like creativity in Hollywood is dead, Every Frame a Painting shows us that behind every shot is a deeper meaning that’s helping the story progress. Every Frame a Painting helps filmmakers think about film on a deeper level.Notable Episode: Edgar Wright – How to Do Visual Comedy 6. Indy Mogul (RIP)Perfect for Indie FilmmakersAbout one year ago, Indie Mogul came to a startling end when the producers couldn’t work out the finances of the channel. However, despite the fact that new content isn’t updated, there is still over 1,200 tutorials dedicated to helping you become a better filmmaker. Seriously, if you have a question? It’s probably already been answered on Indie Mogul!Notable Episode: Slit Throat Effect: DIY Tutorial Subscribing to these YouTube channels for filmmakers is like going to film school for free!Aside from simply going out and creating a film, one of the best ways you can get better as a filmmaker is to simply watch YouTube tutorials about the craft. From pre-production to exporting, these 9 YouTube channels are a fantastic resource for you to take your filmmaking skills to the next level. If you know of any other awesome channels, we’d love to hear about the in the comments below. In the meantime, do yourself a favor and subscribe to all these channels. These truly are great YouTube channels for filmmakers.1. Film RiotPerfect for Indie FilmmakersWhat’s not to love about Film Riot? With a fantastic mixture of comedy and informative information, Film Riot is hands down the best filmmaking channel on YouTube. Every Film Riot tutorial features helpful tips and tricks for you, the filmmaker. Plus the host, Ryan Connolly, is a great filmmaker with a proven track record, so you know you’re learning from a credible source.Notable Episode: $10 DIY Camera Slider! 5. Tom AntosPerfect for Indie FilmmakersWhile it’s hard to say what exactly is the central theme of Tom Antos’s YouTube page, the channel is full of helpful tutorials and tricks designed to help filmmakers master their craft. From gear reviews to lighting tutorials, you can learn it all. It’s especially interesting to see Tom’s own personal films mixed into the videos.Notable Episode: Ultimate GH4 kit and Lenses for Video
A prosthesis is a device designed to replace a missing part of the body, or to make a part of the body work better. The metal prosthetic device in knee joint replacement surgery replaces cartilage and bone which is damaged from disease or aging.Review Date:9/22/2011Reviewed By:C. Benjamin Ma, MD, Assistant Professor, Chief, Sports Medicine and Shoulder Service, UCSF Dept of Orthopaedic Surgery. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
Willow FiddlerAPTN NewsLilly Southwind had a gut feeling not to hand over the pictures of her mom to police.Viola Panacheese had been missing for three days when she reported her missing 25 years ago to the Ontario Provincial Police in Sioux Lookout, Ont.“I gave them reluctantly, cause they didn’t have a current picture of her to post, to share in hopes of finding her,” Lilly said at Day 2 of the Thunder Bay public hearings of the National Inquiry into Missing and Murdered Indigenous Women and Girls.“I told them I want them back right away.”Years passed and Viola is still missing. So are the photos.Lilly kept on police to return the photos and would be shocked when she was finally told what happened to them.“He said, ‘we don’t have your mothers pictures. We don’t have them. Her file was lost,’” said Lilly. She was told it was possible the file ended up in the “burn pile” when the detachment moved into a new building.“I just sat there, I was in shock. My first thought was so when was it lost? How long has it been lost? All that time when things could’ve been done or people could’ve been interviewed again, all that time is gone,” said Lilly.Lilly told the inquiry more needs to be done to help families of missing persons.“I don’t want any family to ever go through that frustration, that angry, that anguish. I feel my family was wronged,” she said.